A conference on Computational Methods applied in various systems will be organized under this title and the 5th Computational Methods in Systems and Software 2021. provides an ON-LINE forum for researchers, practitioners and educators to present and discuss the most recent innovations, trends, experiences and concerns in the field of computer science, software engineering, computational methods, statistics, econometrics, data science, system engineering and artificial intelligence. The CoMeSySo proceedings from 2018 - 2020 are indexed in Web of Science Core Collection - Conference Proceedings Citation Index - Science (CLARIVATE ANALYTICS) and in SCOPUS. CoMeSySo 2021 Paper Submission Date: June 20, 2021 (Conference date: October 15, 2021 - October 17, 2021). Link : http://comesyso.openpublish.eu/